Plasminogen activation with streptokinase

Fibrinogen concentration and coronary artery reperfusion after intravenous anisoylated plasminogen streptokinase activator complex or intracoronary streptokinase therapy. Dose-ranging studies of anisoylated plasminogen streptokinase activator complex — studies in healthy volunteers and in patients with acute myocardial infarction. Rapid lysis of coronary artery thrombi with anisoylated plasminogen: streptokinase activator complex — treatment by bolus intravenous injection. Annals of Internal Medicine —, Intravenous coronary fibrinolysis with acylated streptokinase-plasminogen SQ-PA.

On the fibrinolytic and thrombolytic properties of active-site p-anisoylated streptokinase-plasminogen complex BRL Meinertz T. Randomised multicentre trial of anisoylated plasminogen streptokinase activator complex versus heparin — interim results.

Evaluation of the effectiveness of intracoronary streptokinase infusion in myocardial infarction: postprocedure management and hospital course in patients.

American Heart Journal —, Monassier JP, Hanssen M. Haematological effects of anisoylated plasminogen streptokinase activator complex and streptokinase in patients with acute myocardial infarction. Safety and side effects of anisoylated plasminogen streptokinase activator complex and streptokinase in patients with acute myocardial infarction. Pharmacokinetic properties of anisoylated plasminogen streptokinase activator complex and other thrombolytics in animals and in man.

Ogston D, Bennett B. Surface-mediated reactions in the formation of thrombin, plasmin and kallikrein. British Medical Bulletin —, Anticoagulant, antithrombotic and thrombolytic drugs. In Goodman et al. Eds The pharmacological basis of therapeutics, 7th ed. Proteolysis of fibrinogen in healthy volunteers following major and minor in vivo plasminogen activation.

Thrombosis Research 91—97, b. A comparison of acylated streptokinase-plasminogen complex and streptokinase in healthy volunteers. Thrombosis and Haemostasis —, a. Analysis of coagulation and fibrinolysis after intravenous anisoylated plasminogen streptokinase activator complex or heparin in patients with acute myocardial infarction — a Belgian multicentre study. Rothbard RL. Comparative tolerance and complications in a multicentre trial of intracoronary streptokinase and intravenous anisoylated plasminogen streptokinase activator complex in acute myocardial infarction.

Biological study of intravenous anisoylated plasminogen streptokinase activator complex in acute myocardial infarction. Evaluation of two intravenous thrombolytic agents anisoylated plasminogen streptokinase activator complex versus streptokinase in patients with acute myocardial infarction.

Smith RAG. Non-exchange of streptokinase from acylated streptokinase plasminogen complexes. Fibrinolysis with acyl enzymes: a new approach to thrombolytic therapy. Acyl-enzymes as thrombolytic agents in a rabbit model of venous thrombosis. Acute coronary occlusion and reperfusion: reliability of angiographic classification and grading.

Spann JF, Sherry S. Coronary thrombolysis for evolving myocardial infarction. Drugs —, Streptokinase and anisoylated streptokinase plasminogen complex — their action on haemostasis in human volunteers.

European Journal of Clinical Pharmacology —, Assessment of left ventricular function in a randomised study of intravenous anisoylated plasminogen streptokinase activator complex versus heparin in acute myocardial infarction — Preliminary results of the European Multicentre Study Belgian centres.

Thompson RB Ed. Disorders of the blood: a textbook of clinical haematology pp. An interim report of a double-blind placebo controlled recanalisation study of anisoylated plasminogen streptokinase activator complex in acute myocardial infarction. Single dose intravenous thrombolysis in acute myocardial infarction: a non-invasive evaluation of a streptokinase-plasminogen activator complex BRL British Heart Journal 79, Efficacy and safety of BRL , a new fibrinolytic agent for intravenous administration in acute myocardial infarction.

Circulation 70 Suppl. II : , Randomised trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction. Lancet 1: —, Verstraete M, Verwilghen R.

Haematological disorders. In Avery GS Ed. Drug treatment: principles and practice of clinical pharmacology and therapeutics, 2nd ed.

Intracoronary thrombus in syndromes of unstable myocardial ischemia. Acylated streptokinase-plasminogen complex in patients with acute myocardial infarction.

Wiman B, Collen D. Molecular mechanism of physiological fibrinolysis. On the specific interaction between lysine-binding sites in plasmin and complementary sites in alphaantiplasmin and fibrinogen. Biochimica et Biophysica Acta —, Download references. You can also search for this author in PubMed Google Scholar.

Various sections of the manuscript reviewed by: D. Germany; S. Reprints and Permissions. Monk, J. Drugs 34, 25—49 Download citation. Published : 23 October Issue Date : July Anyone you share the following link with will be able to read this content:. The gel-filtration behaviour of proteins related to their molecular weights over a wide range. J Biol Chem. Ann N Y Acad Sci. Interaction of streptokinase and human plasminogen. Further gel electrophoretic studies on the combination of streptokinase with human plasminogen or human plasmin.

Preparation and certain properties of highly purified streptokinase. Plasmin and activator activities in reaction mixtures of streptokinase and human plasminogen or human plasmin of various molar ratios. Proactivator function of human plasmin as shown by lysine esterase assay.

Mechanism of formation of bovine plasminogen activator from human plasmin. Isolation and characterization of bovine plasminogen activator from a human plasminogen-streptokinase mixture. A method of trace iodination of proteins for immunologic studies.

Int Arch Allergy Appl Immunol. Comparison of human plasmins formed by activation with trace and large amounts of streptokinase. J Biochem. Studies of the plasmin system. Measurement of human and animal plasminogen; measurement of an activator in human serum. J Exp Med. Robert I. Krasner and Genevieve Young. Author information Article notes Copyright and License information Disclaimer.

Received Mar This article has been cited by other articles in PMC. Abstract Human plasminogen, plasma, or serum increased the pathogenicity of six streptokinase-positive streptococcal strains for mice.

J Clin Invest. The activation of human plasminogen by streptokinase. J Biol Chem. Studies on streptococci. A study of the relationship of certain virulence factors in streptococcal infections to the LD 50 dose of streptococci.